Caeiro F, Baptista V, Rodrigues N, Carvalho D, Aires I, Remédio F, Nolasco F
Department of Nephrology, Hospital Curry Cabral, Lisboa, Portugal.
Transplant Proc. 2011 Jan-Feb;43(1):259-62. doi: 10.1016/j.transproceed.2011.01.001.
Chronic hepatitis C virus (HCV) infection exists in a large proportion of patients undergoing renal transplantation. Nowadays it is not considered to be an absolute contraindication to transplantation; however, it is associated with an increased risk for the patient and accounts for a shorter half-life of the renal allograft. We present three transplant recipients who displayed serious hepatic dysfunction after renal transplantation due to an HCV infection. In two of these cases, the liver biopsies established the diagnosis of FCH. In the third case, the liver biopsy was compatible with the early stages of FCH. All patients were started on peg-interferon alfa 2-b and ribavirin with subsequent normalization of hepatic function and early complete viral responses.
慢性丙型肝炎病毒（HCV）感染在接受肾移植的患者中占很大比例。如今，它不被视为移植的绝对禁忌症；然而，它会增加患者的风险，并导致肾移植的半衰期缩短。我们报告了三名肾移植受者，他们因HCV感染在肾移植后出现严重肝功能障碍。其中两例经肝活检确诊为纤维性胆汁淤积性肝炎（FCH）。第三例肝活检结果与FCH早期阶段相符。所有患者均开始使用聚乙二醇化干扰素α-2b和利巴韦林治疗，随后肝功能恢复正常并出现早期完全病毒应答。
