Goluza Eleonora, Hudolin Tvrtko, Kastelan Zeljko, Peric Mladen, Murselovic Tamara, Sosic Hrvoje
Department of Anesthesiology, Reanimatology and Intensive Care, KBC Zagreb, Kispaticeva 12, Zagreb, Croatia.
Urol Int. 2011;86(3):315-9. doi: 10.1159/000323836. Epub 2011 Feb 19.
To investigate analgesia using lidocaine suppositories for prostate biopsy.
From 2007 to 2009, 160 patients underwent transrectal ultrasound-guided prostate biopsy at the Department of Urology, KBC Zagreb. 80 patients received a 60-mg lidocaine suppository intrarectally at different time points from 15 to 120 min before biopsy and 80 patients received a glycerin suppository as placebo. The pain level was evaluated using a visual analogue scale (VAS).
There were no statistically significant differences between the groups, i.e. they were similar regarding patients' age, prostate-specific antigen levels, prostate volume and the incidence of diagnosis of malignancy on biopsy. The mean pain score in the lidocaine group (3 ± 1) was significantly lower than the mean pain score in the glycerin group (4.1 ± 1.3) (p < 0.001). A noticeable trend towards lower pain scores in the lidocaine group was observed with more time elapsing from placing the suppository till the biopsy and the optimal time for performing biopsy starting approximately 1 h after placing the suppository.
Lidocaine suppositories are an easy-to-use, self-applicable (by the patient) and cheap method of local analgesia, with acceptable results. Possible complications related to this procedure are insignificant.
研究利多卡因栓剂用于前列腺活检的镇痛效果。
2007年至2009年，160例患者在萨格勒布KBC泌尿外科接受经直肠超声引导下的前列腺活检。80例患者在活检前15至120分钟的不同时间经直肠给予60毫克利多卡因栓剂，80例患者给予甘油栓剂作为安慰剂。使用视觉模拟量表（VAS）评估疼痛程度。
两组之间无统计学显著差异，即患者年龄、前列腺特异性抗原水平、前列腺体积以及活检时恶性肿瘤诊断发生率方面相似。利多卡因组的平均疼痛评分（3±1）显著低于甘油组（4.1±1.3）（p<0.001）。从放置栓剂到活检的时间越长，利多卡因组疼痛评分越低的趋势越明显，活检的最佳时间约为放置栓剂后1小时。
利多卡因栓剂是一种易于使用、患者可自行应用且廉价的局部镇痛方法，效果尚可。与此操作相关的可能并发症不严重。
