Dimković N, Ramić Z, Djukanović Lj, Trbolević S, Lukić M
Institute for Renal Diseases, Zvezdara Clinical and Hospital Centre.
Srp Arh Celok Lek. 1990 Nov-Dec;118(11-12):435-40.
Sera of patients suffering from Balkan nephropathy, pyelonephritis and glomerulonephritis inhibit lectin-induced T-cell proliferation in vitro. Immunosuppressive factors were registered in the patients' sera during the early stage of the existing disease, and their activity was not in correlation with the degree of renal insufficiency. Serum inhibitors revealed their activity during the early phase of T-cell activation and had no effect on T-cell proliferation and DNK synthesis. Inhibitor activity was registered even if sera were not present in cell culture continuously but only 6 hours of preincubation; then their action was irretrievable.
患有巴尔干肾病、肾盂肾炎和肾小球肾炎的患者血清在体外可抑制凝集素诱导的T细胞增殖。在现有疾病的早期阶段，患者血清中检测到免疫抑制因子，其活性与肾功能不全程度无关。血清抑制剂在T细胞激活的早期阶段显示出活性，对T细胞增殖和DNA合成没有影响。即使细胞培养中血清不是持续存在，而仅预孵育6小时，也能检测到抑制剂活性；然后其作用是不可逆的。
