Belovezhdov N, Altankova I
Clin Nephrol. 1982 Mar;17(3):141-8.
Blood levels of E-rosette forming cells, HbsAg, C3 and immunoglobulins G, A and M were determined in a series of 101 patients with different forms of glomerulonephritis. Cell-mediated immunity to glomerular basement membrane (GBM) antigens and renal tubular epithelial (RTE) antigen was studied in 39 patients with glomerulonephritis and in 53 patients with Balkan nephropathy (BEN). The patients with glomerulonephritis had statistically higher serum levels of IgG, IgA and IgM than normal individuals. Decreased serum C3 values were recorded in 40.6 per cent of the patients and circulating immune complexes (CIC) were detected in 47.5 per cent; 6.9 per cent of the patients were HBsAg positive. The patients' levels of E-rosette forming cells were significantly lower than those of healthy controls. Cell-mediated immunity to GBM was recorded in 53.8 per cent of the patients with chronic glomerulonephritis and to RTE-antigen in 58.5 per cent of the patients with BEN. These changes are interpreted as being a manifestation of an abnormal immune response, characterized by disorders of T lymphocyte function and activation of B lymphocytes. Evidence for this includes the presence of CICs, the low C3 levels the high number of positive tests for HBsAg.
对101例患有不同类型肾小球肾炎的患者测定了E玫瑰花结形成细胞、乙肝表面抗原、补体C3以及免疫球蛋白G、A和M的血药浓度。对39例肾小球肾炎患者和53例巴尔干肾病（BEN）患者研究了针对肾小球基底膜（GBM）抗原和肾小管上皮（RTE）抗原的细胞介导免疫。肾小球肾炎患者的血清IgG、IgA和IgM水平在统计学上高于正常个体。40.6%的患者血清C3值降低，47.5%的患者检测到循环免疫复合物（CIC）；6.9%的患者乙肝表面抗原呈阳性。患者的E玫瑰花结形成细胞水平显著低于健康对照。53.8%的慢性肾小球肾炎患者和58.5%的BEN患者存在针对GBM的细胞介导免疫以及针对RTE抗原的细胞介导免疫。这些变化被解释为异常免疫反应的表现，其特征为T淋巴细胞功能紊乱和B淋巴细胞激活。支持这一观点的证据包括CIC的存在、低C3水平以及大量乙肝表面抗原阳性检测结果。
