LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York 10022, USA.
Retina. 2011 Mar;31(3):441-5. doi: 10.1097/IAE.0b013e3181fe54fa.
To investigate the spectral-domain optical coherence tomography findings in four cases of acute macular neuroretinopathy and identify features that may differentiate acute macular neuroretinopathy from similar conditions in the acute zonal occult outer retinopathy complex.
Patients with acute macular neuroretinopathy underwent complete periodic examinations, including ophthalmoscopy, color photography and autofluorescence photography, visual field testing, and spectral-domain optical coherence tomography. Abnormalities as seen by multimodal imaging were documented and evaluated during follow-up.
The average age of the 4 patients was 32 years (range, 28-34 years), and 2 had bilateral involvement. The follow-up ranged from 1 month to 5 months. In each patient, dark lobular areas seen by ophthalmoscopy corresponded to the measured visual field defect and what appeared to be a regional loss of outer segments of the photoreceptors. The outer segment defect resolved in two patients and improved in the other two during follow-up. All patients showed a colocalizing regional thinning of the outer nuclear layer, which did not change during the follow-up period. There were no associated abnormalities in the fundus appearance.
Acute macular neuroretinopathy causes reddish brown patches that are because of outer retinal damage as documented by spectral-domain optical coherence tomography. Unlike other entities in the acute zonal occult outer retinopathy complex, acute macular neuroretinopathy has no other synchronic ophthalmoscopically visible fundus abnormalities. These lesions may resolve over time, with restoration of the outermost retinal architecture, but persistent thinning of the overlying outer nuclear layer remained.
研究 4 例急性黄斑神经视网膜病变的光谱域光相干断层扫描（OCT）结果，以识别可能将急性黄斑神经视网膜病变与急性区域性隐匿性外层视网膜病变（AZOOR）复合体中类似疾病区分开来的特征。
对急性黄斑神经视网膜病变患者进行全面的定期检查，包括检眼镜、彩色照相和自发荧光照相、视野测试和光谱域 OCT。记录多模态成像所见的异常，并在随访期间进行评估。
4 例患者的平均年龄为 32 岁（范围 28-34 岁），2 例为双侧受累。随访时间为 1 个月至 5 个月。在每位患者中，检眼镜所见的暗叶状区域与测量的视野缺损以及似乎是光感受器外层的局灶性丧失相对应。2 例患者的外层节段缺陷在随访中得到解决，另外 2 例患者得到改善。所有患者均表现出外核层局灶性变薄，且在随访期间未发生变化。眼底外观无其他相关异常。
急性黄斑神经视网膜病变导致棕红色斑块，这是由光谱域 OCT 记录的外视网膜损伤引起的。与急性区域性隐匿性外层视网膜病变复合体中的其他病变不同，急性黄斑神经视网膜病变没有其他同步的检眼镜可见眼底异常。这些病变可能随时间而消退，最外层视网膜结构得以恢复，但覆盖其上的外核层仍持续变薄。
