Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam, The Netherlands.
Nat Neurosci. 2011 Apr;14(4):417-9. doi: 10.1038/nn.2770. Epub 2011 Feb 20.
Tobacco smoking and nicotine exposure during adolescence interfere with prefrontal cortex (PFC) development and lead to cognitive impairments in later life. The molecular and cellular underpinnings of these consequences remain elusive. We found that adolescent nicotine exposure induced lasting attentional disturbances and reduced mGluR2 protein and function on presynaptic terminals of PFC glutamatergic synapses. Restoring mGluR2 activity in vivo by local infusion of a group II mGluR agonist in adult rats that received nicotine as adolescents rescued attentional disturbances.
青少年时期吸烟和尼古丁暴露会干扰前额叶皮层（PFC）的发育，并导致以后生活中的认知障碍。这些后果的分子和细胞基础仍然难以捉摸。我们发现，青少年时期的尼古丁暴露会导致持续的注意力障碍，并减少 PFC 谷氨酸能突触前末梢的 mGluR2 蛋白和功能。在青少年时期接受尼古丁处理的成年大鼠中，通过局部输注 II 组代谢型谷氨酸受体激动剂来恢复体内 mGluR2 活性，可挽救注意力障碍。
