用于脑膜炎球菌病的外膜蛋白囊泡疫苗。
Outer membrane protein vesicle vaccines for meningococcal disease.
作者信息
Frasch C E, van Alphen L, Holst J, Poolman J T, Rosenqvist E
机构信息
Division of Bacterial Products, Center for Biologics Evaluation and Research, Rockville, MD.
出版信息
Methods Mol Med. 2001;66:81-107. doi: 10.1385/1-59259-148-5:81.
PMID:21336749
Abstract
Alternative strategies exist for prevention of group B Neisseria meningitidis (meningococcal) disease through vaccination (see Chapters 5 , 8 , 13 , 14 in this volume). However, the most promising approach to date has been the use of outer-membrane vesicle (OMV) vaccines for induction of bactericidal antibodies against cell-surface outer-membrane proteins (OMPs).
摘要
通过接种疫苗预防B群脑膜炎奈瑟菌（脑膜炎球菌）病存在其他策略（见本卷第5、8、13、14章）。然而，迄今为止最有前景的方法是使用外膜囊泡（OMV）疫苗来诱导针对细胞表面外膜蛋白（OMP）的杀菌抗体。
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