Ison C A
Department of Infectious Diseases ⇐p; Microbiology, Imperial College School of Medicine, London, UK.
Methods Mol Med. 2001;66:317-29. doi: 10.1385/1-59259-148-5:317.
Neisseria meningitidis is an obligate human pathogen. When it interacts with the host, it can establish a commensal relationship or can, on a minority of occasions, invade and cause systemic disease. Protection against systemic disease, particularly for serogroup A and C infections, has been equated with the presence of bactericidal antibody directed against the capsular polysaccharide (CPS) (1). In serogroup B infections, the CPS resembles host-cell moieties, is non-immunogenic, and does not induce protection (2). Hence other components of the bacterial-cell envelope, such as outer-membrane proteins (OMPs), and cellular mechanisms of host defense, such as phagocytosis, have been implicated in immunity to serogroup B infections (3,4).
脑膜炎奈瑟菌是一种专性人类病原体。当它与宿主相互作用时，它可以建立共生关系，或者在少数情况下，侵入并引起全身性疾病。预防全身性疾病，特别是针对A群和C群感染，已等同于存在针对荚膜多糖（CPS）的杀菌抗体（1）。在B群感染中，CPS类似于宿主细胞成分，无免疫原性，不诱导保护作用（2）。因此，细菌细胞膜的其他成分，如外膜蛋白（OMPs），以及宿主防御的细胞机制，如吞噬作用，已被认为与B群感染的免疫有关（3,4）。
