Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes 1, Catalyse et Organometalliques, Campus de Beaulieu, 35042 Rennes, France.
ChemSusChem. 2011 Apr 18;4(4):526-34. doi: 10.1002/cssc.201000405. Epub 2011 Feb 18.
Some ethers, such as cyclopentyl methyl ether and di-n-butyl ether, which can be considered as "greener" solvents than N,N-dimethylacetamide (DMAc) or DMF, can be advantageously employed for the palladium-catalyzed direct arylation of heteroaromatics. In the presence of such ethers and only 0.5-1 mol % of palladium catalysts at 125-150 °C, the direct 5-arylation of thiazoles, thiophenes, or furans by using aryl bromides as coupling partners proceeds in moderate to high yields.
一些醚类，如环戊基甲基醚和二正丁基醚，可以被认为是比 N,N-二甲基乙酰胺（DMAc）或 DMF 更“环保”的溶剂，可用于钯催化的杂芳烃直接芳基化反应。在这些醚类的存在下，仅使用 0.5-1 mol%的钯催化剂，在 125-150°C 的温度下，使用芳基溴作为偶联试剂，噻唑、噻吩或呋喃的直接 5-芳基化反应可以中等至高产率进行。
