Aridis Pharmaceuticals, San Jose, California 95138, USA.
J Pharm Sci. 2011 Jun;100(6):2020-53. doi: 10.1002/jps.22458. Epub 2011 Feb 18.
Trehalose, a disaccharide of glucose, has been reported to accumulate in many organisms that can withstand extended periods of inanimation. Since this discovery, the properties of trehalose have been examined extensively to understand its role and abundance in nature. The unique features of this sugar became clearer with each new finding which demonstrated its ability to sustain and preserve a wide array of biological molecules. Trehalose has been used in a variety of research applications and is contained in several commercially available therapeutic products, including Herceptin®, Avastin®, Lucentis®, and Advate®. Currently, there is a growing interest in the use of trehalose in solid dosage formulations, most notably in quick-dissolving tablets. Furthermore, trehalose has found its use in several food and cosmetic products, and new applications capitalizing on its unique properties are being developed and implemented in everyday-use products. As trehalose is an approved ingredient in all major markets, there is no significant barrier to its use. Extensive work with trehalose has been conducted in the three major industries, however with little overlap. Further understanding of the role of trehalose in the various applications may lead to an increase in the number of trehalose-containing products.
海藻糖是一种葡萄糖的二糖，已被报道在许多能够长时间处于无生命状态的生物体中积累。自这一发现以来，人们对海藻糖的性质进行了广泛的研究，以了解其在自然界中的作用和丰度。随着每一个新发现，这种糖的独特性质变得更加清晰，证明了它能够维持和保护广泛的生物分子的能力。海藻糖已被用于各种研究应用中，并且包含在几种市售的治疗产品中，包括赫赛汀、阿瓦斯汀、雷珠单抗和艾美赛珠单抗。目前，人们对海藻糖在固体制剂中的应用越来越感兴趣，尤其是在速溶片剂中。此外，海藻糖已在几种食品和化妆品产品中得到应用，并且正在开发和实施利用其独特性质的新应用，以应用于日常使用的产品中。由于海藻糖在所有主要市场都是一种经过批准的成分，因此其使用没有重大障碍。在三大主要行业中都对海藻糖进行了广泛的研究，但相互之间的重叠较少。对海藻糖在各种应用中的作用的进一步理解可能会导致含海藻糖产品的数量增加。
