Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
J Surg Oncol. 2011 Mar 1;103(3):239-42. doi: 10.1002/jso.21813. Epub 2010 Dec 7.
Adenosquamous/squamous cell carcinoma (AS/SCC) of the gallbladder is rarely encountered and accounts for 1.4-10.6% of all gallbladder carcinomas (GBCs). This study was conducted to investigate the clinicopathologic features of AS/SCC of gallbladder.
The authors retrospectively reviewed 16 cases of pathologically proven AS/SCC of the gallbladder among 404 patients who underwent surgery for GBC from October 1994 to March 2009. Forty-eight conventional GBC patients were selected as controls after matching for age and gender.
Mean patient age was 60.2 years and half were male. Tumor stages in the case group were significantly more advanced than the control group (P < 0.001). R0 resection rates in cases and controls were 50% and 81.2% (P = 0.022). Overall 1-year survival in the case group was significantly poorer than in the control group (18.8% vs. 87.3%, P < 0.001). However, no significant difference in disease-free survival rates was found between cases and controls after R0 resection (P = 0.072).
AS/SCC of the gallbladder is often diagnosed at an advanced stage, which results in non-curative surgical resection and a poorer prognosis than conventional GBC. However, curative surgical resection of AS/SCC of the gallbladder might result in disease-free survival rates that are comparable with those of conventional GBC.
胆囊腺鳞/鳞细胞癌（AS/SCC）很少见，占所有胆囊癌（GBC）的 1.4-10.6%。本研究旨在探讨胆囊 AS/SCC 的临床病理特征。
作者回顾性分析了 1994 年 10 月至 2009 年 3 月期间因 GBC 接受手术治疗的 404 例患者中经病理证实的 16 例胆囊 AS/SCC。选择 48 例常规 GBC 患者作为年龄和性别匹配的对照组。
患者平均年龄为 60.2 岁，男性占一半。病例组的肿瘤分期明显比对照组更晚（P < 0.001）。病例组和对照组的 R0 切除率分别为 50%和 81.2%（P = 0.022）。病例组的总 1 年生存率明显低于对照组（18.8% vs. 87.3%，P < 0.001）。然而，在 R0 切除后，病例组和对照组的无病生存率无显著差异（P = 0.072）。
胆囊 AS/SCC 通常在晚期诊断，导致无法治愈的手术切除，预后比常规 GBC 差。然而，胆囊 AS/SCC 的根治性手术切除可能导致无病生存率与常规 GBC 相当。
