Vorob'eva N Iu, Boeva O V, Osipov A N, Bozhenko V K
Vestn Rentgenol Radiol. 2008(4-6):50-4.
DNA double-stranded breaks and their association with the development of radiation-induced peripheral lymphocyte apoptosis were studied in healthy donors exposed to in vitro gamma-irradiation in a dose of 1 Gy. It was shown that irradiation in 1-Gy dose caused a significant (p < 0.05) increase in the frequency of cells in late apoptosis 4 hours after irradiation and a rise in their frequency in early apoptosis 24 hours following this procedure. A significant correlation (r = 0.52, p < 0.05) was recorded between the primary level of radiation-induced DNA double-stranded breaks and the frequency of cells in late apoptosis following 4 hours, which suggests that DNA double-stranded breaks as a signal to trigger cell apoptotic death are of great importance.
对接受1 Gy体外γ射线照射的健康供体，研究了DNA双链断裂及其与辐射诱导外周淋巴细胞凋亡发生的关系。结果表明，1 Gy剂量照射后4小时，晚期凋亡细胞频率显著增加（p < 0.05），此操作后24小时，早期凋亡细胞频率上升。辐射诱导的DNA双链断裂初始水平与4小时后晚期凋亡细胞频率之间存在显著相关性（r = 0.52，p < 0.05），这表明DNA双链断裂作为触发细胞凋亡死亡的信号具有重要意义。
