Semiconductor Electronics Division, Electronics and Electrical Engineering Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
J Phys Condens Matter. 2010 Nov 17;22(45):454108. doi: 10.1088/0953-8984/22/45/454108. Epub 2010 Oct 29.
The ion channel formed by Staphylococcus aureus alpha-hemolysin switches between multiple open conducting states. We describe a method for precisely estimating the changes in the ion channel geometry that correspond to these different states. Experimentally, we observed that the permeability of a single channel to differently sized poly(ethylene glycol) molecules depends on the magnitude of the open state conductance. A simple theory is proposed for determining changes in channel length of 4.2% and in cross-sectional area of -0.4%.
金黄色葡萄球菌α-溶血素形成的离子通道在多个开放传导状态之间切换。我们描述了一种精确估计对应于这些不同状态的离子通道几何形状变化的方法。在实验中，我们观察到单个通道对不同大小的聚乙二醇分子的渗透性取决于开放状态电导的大小。提出了一个简单的理论来确定通道长度的变化为 4.2%，横截面积的变化为-0.4%。
