Department of Family Medicine, Case Western Reserve University School of Medicine, Berea, OH, USA.
Clin Hemorheol Microcirc. 2011;47(2):79-86. doi: 10.3233/CH-2010-1369.
Fluid retention increases intravascular volume and pressure. The calculations in this paper demonstrate that fluid retention increases the likelihood that blood will flow in a turbulent manner, in part due to an increase in stroke volume, regardless of whether or not blood pressure is increased. Increased turbulence will promote endothelial dysfunction, thereby contributing to the development of atherosclerotic cardiovascular disease. Accordingly, fluid retention is predictably detrimental to the cardiovascular system. The reason that some medications, such as cyclo-oxygenase-2 inhibitors, nonselective nonsteroidal anti-inflammatory drugs, estrogens, progestins, and rosiglitazone, are associated with an increased risk of myocardial infarcts and strokes may be that they cause fluid retention. Increased stroke volume and/or edema formation may indicate that a medication increases the risk of adverse cardiovascular events. For drugs that increase the risk of adverse cardiovascular events, it may be possible to reduce or neutralize the increased risk by simultaneously administering a diuretic.
体液潴留会增加血管内的容积和压力。本文的计算表明，无论血压是否升高，体液潴留都会增加血液以湍流方式流动的可能性，部分原因是心搏量增加。湍流的增加会促进内皮功能障碍，从而导致动脉粥样硬化性心血管疾病的发展。因此，体液潴留可预测地对心血管系统有害。某些药物，如环氧化酶-2 抑制剂、非选择性非甾体抗炎药、雌激素、孕激素和罗格列酮，与心肌梗死和中风风险增加有关，原因可能是它们导致体液潴留。心搏量增加和/或水肿形成可能表明药物会增加不良心血管事件的风险。对于增加不良心血管事件风险的药物，通过同时使用利尿剂，可能可以降低或中和增加的风险。
