Department of Radiology, The Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.
Neurol India. 2011 Jan-Feb;59(1):108-10. doi: 10.4103/0028-3886.76884.
Neuroimaging findings in 1,2-dichloroethane (1,2-DCE) encephalopathy have seldom been reported. We present the comprehensive neuroimaging findings, conventional magnetic resonance imaging (MRI) combined with diffusion tensor imaging (DTI) and 1 H-magnetic resonance spectroscopy ( 1 H-MRS), in a case of 1,2-DCE encephalopathy. On day-4 the signal intensity of the lesions on diffusion-weighted imaging (DWI) was higher than that with T2-weighted imaging (T2WI); mean apparent diffusion coefficient (ADC) values for lesions were lower than control values. On day-20, the mean ADC value was increased gradually, whereas the mean fractional anisotropy (FA) of the lesions was significantly reduced. 1 H-MRS showed reduced ratios of N-acetyl aspartate to creatinine (NAA/Cr) and NAA to choline (NAA/Cho) on day-20 as compared with the control values. Combining conventional MRI with DTI and MRS is valuable in the early diagnosis and prognosis of 1,2-DCE-induced encephalopathy.
二氯乙烷（1,2-DCE）脑病的神经影像学表现鲜有报道。我们报告了一例 1,2-DCE 脑病的全面神经影像学表现，包括常规磁共振成像（MRI）联合弥散张量成像（DTI）和氢质子磁共振波谱（1 H-MRS）。在发病第 4 天，病变的弥散加权成像（DWI）信号强度高于 T2 加权成像（T2WI）；病变的平均表观弥散系数（ADC）值低于对照值。在发病第 20 天，平均 ADC 值逐渐升高，而病变的部分各向异性（FA）值显著降低。与对照值相比，1 H-MRS 显示发病第 20 天病变的 N-乙酰天门冬氨酸与肌酸（NAA/Cr）和 N-乙酰天门冬氨酸与胆碱（NAA/Cho）比值降低。常规 MRI 联合 DTI 和 MRS 对 1,2-DCE 诱导的脑病的早期诊断和预后具有重要价值。
