[糖尿病诱导的高血压大鼠的全身血流动力学和左心室功能]
[Systemic hemodynamic and left ventricular function of diabetic-induced hypertensive rats].
作者信息
Cesaretti Mário Luís Ribeiro, Ginoza Milton, Ribeiro Artur Beltrame, Kohlmann Osvaldo
机构信息
Disciplina de Nefrologia, Universidade Federal de São Paulo, SP, Brasil.
出版信息
Arq Bras Endocrinol Metabol. 2010 Dec;54(9):842-51. doi: 10.1590/s0004-27302010000900011.
OBJECTIVE
To analyze the effects of type-1 diabetes mellitus (DM1) induction on systemic hemodynamic and ventricular function of normotensive and hypertensive rats.
MATERIALS AND METHODS
DM1 was induced by streptozotocin in Wistar rats (WST), borderline hypertensive rats (BHR) and spontaneously hypertensive rats (SHR). The systemic hemodynamic was evaluated by thermodilution and ventricular function by Langendorff preparation.
RESULTS
DM1-induction increased tail arterial pressure of WST and BHR. DM1 also increased total peripheral resistance in WST and decrease in cardiac output stroke volume in WST and BHR. Systolic function indexes were reduced and ventricular stiffness increased in all WST-diabetic rats. All of these effects were more prominent on diabetic WST rats.
CONCLUSION
The DM1 in rats was accompanied by important changes in both systolic and diastolic heart function leading to significant changes in the systemic hemodynamics that were not significantly enhanced by hypertension.
目的
分析1型糖尿病（DM1）诱导对正常血压和高血压大鼠全身血流动力学及心室功能的影响。
材料与方法
用链脲佐菌素在Wistar大鼠（WST）、临界高血压大鼠（BHR）和自发性高血压大鼠（SHR）中诱导DM1。通过热稀释法评估全身血流动力学，通过Langendorff标本评估心室功能。
结果
DM1诱导使WST和BHR的尾动脉压升高。DM1还使WST的总外周阻力增加，使WST和BHR的心输出量和每搏输出量减少。所有WST糖尿病大鼠的收缩功能指标降低，心室僵硬度增加。所有这些影响在糖尿病WST大鼠中更为显著。
结论
大鼠中的DM1伴随着心脏收缩和舒张功能的重要变化，导致全身血流动力学发生显著变化，而高血压并未显著增强这些变化。
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