有氧运动和多柔比星暴露的小鼠心脏功能：荟萃分析。
Aerobic Exercise and Cardiac Function of Murines Exposed to Doxorubicin: a Meta-Analysis.
机构信息
Universidade do Estado do Rio de Janeiro - Programa de Pós-Graduação em Ciências do Exercício e do Esporte, Rio de Janeiro, RJ - Brasil.
Universidade do Estado do Rio de Janeiro - Grupo de Pesquisa em Ciências do Exercício e da Saúde, Rio de Janeiro, RJ - Brasil.
出版信息
Arq Bras Cardiol. 2020 Nov;115(5):885-893. doi: 10.36660/abc.20190260.
BACKGROUND
Cardiotoxicity may be a consequence of treatments with doxorubicin (DOX).
OBJECTIVES
To investigate the effect of aerobic exercise on the prevention of cardiac dysfunction in murines exposed to DOX.
METHOD
A comprehensive search was conducted in 9 databases in December 2017. Studies that evaluated the cardiac function of murines exposed to DOX were included. The significance level adopted was 5%.
RESULTS
In a comparison between 230 murines that underwent aerobic exercise plus DOX treatment and 222 control murines (DOX treatment only), fractional shortening showed an improvement of 5.33% in favor of the experimental group (p = 0.00001). Left ventricle developed pressure also showed an increase of 24.84 mm Hg in favor of the group of 153 murines that performed exercise in comparison to the control group of 166 murines (p = 0.00001).
CONCLUSION
Preclinical studies included in this meta-analysis indicated that exercise is a good nonpharmacological strategy for preserving post-DOX cardiac function.
背景
多柔比星（DOX）治疗可能会导致心脏毒性。
目的
研究有氧运动对预防 DOX 暴露小鼠心脏功能障碍的影响。
方法
2017 年 12 月，在 9 个数据库中进行了全面检索。纳入评估 DOX 暴露小鼠心脏功能的研究。采用 5%的显著性水平。
结果
在接受有氧运动加 DOX 治疗的 230 只小鼠和仅接受 DOX 治疗的 222 只对照小鼠之间的比较中，实验组的分数缩短改善了 5.33%（p = 0.00001）。与对照组的 166 只小鼠相比，进行运动的 153 只小鼠的左心室发展压也增加了 24.84mmHg（p = 0.00001）。
结论
本荟萃分析纳入的临床前研究表明，运动是一种保持 DOX 后心脏功能的良好非药物策略。
Zotero 插件