Mewissen M W, Minor P L, Beyer G A, Lipchik E O
Department of Radiology, Veterans Administration Medical Center, Milwaukee, WI 53295.
J Vasc Interv Radiol. 1990 Nov;1(1):43-7. doi: 10.1016/s1051-0443(90)72501-8.
"Over-the-wire" thrombolysis was successfully accomplished in eight patients with symptomatic lower-extremity ischemia. The authors used a 5-F catheter with multiple side holes designed to pulse-spray urokinase directly over the guidance of a 0.035-inch guide wire. The mean occlusion length was 11.5 cm (range, 5-27 cm). Complete thrombolysis was achieved after delivery of a mean of 480,000 IU of urokinase in a mean infusion time of 48 minutes. One embolic complication was successfully treated with the catheter-wire system. No bleeding complications occurred. Over-the-wire thrombolysis is an alternative method of administering urokinase for the treatment of arterial occlusions.
8例有症状的下肢缺血患者成功完成了“通过导丝”溶栓治疗。作者使用了一种带有多个侧孔的5F导管，该导管设计用于在0.035英寸导丝的引导下直接脉冲喷射尿激酶。平均闭塞长度为11.5厘米（范围为5 - 27厘米）。平均输注时间48分钟，平均输注480,000国际单位尿激酶后实现了完全溶栓。1例栓塞并发症通过导管-导丝系统成功治疗。未发生出血并发症。通过导丝溶栓是一种给予尿激酶治疗动脉闭塞的替代方法。
