Bookstein J J, Valji K
Department of Radiology, University of California, San Diego Medical Center 92103-1990.
Cardiovasc Intervent Radiol. 1992 Jul-Aug;15(4):228-33. doi: 10.1007/BF02733928.
The synergistic potential of combining pharmacologic and mechanical methods of thrombolysis has recently been recognized. Pulse-spray pharmacomechanical thrombolysis is one such method, which in our experience has markedly increased the efficiency and acceptability of thrombolysis. With this technique, dialysis grafts usually require only 20-35 min for thrombolysis; bypass grafts or native arteries usually require 60-150 min. The entire procedure is accomplished in one session within the angiography suite, including the supplemental transluminal angioplasty, atherectomy, or stenting that is usually also necessary. Clear understanding of the principle of the method and meticulous attention to technical details is essential for maximal speed, safety, and efficacy.
药物溶栓与机械溶栓联合应用的协同潜力最近已得到认可。脉冲喷射药物机械溶栓就是这样一种方法，根据我们的经验，它显著提高了溶栓的效率和可接受性。采用这种技术，透析移植物的溶栓通常只需20 - 35分钟；旁路移植物或天然动脉通常需要60 - 150分钟。整个过程在血管造影室一次完成，包括通常也需要的补充性腔内血管成形术、旋切术或支架置入术。清楚理解该方法的原理并严格关注技术细节对于实现最大速度、安全性和有效性至关重要。
