Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 751 89 Uppsala, Sweden.
Arch Virol. 2011 Jun;156(6):1041-4. doi: 10.1007/s00705-011-0948-5. Epub 2011 Feb 22.
The Chinese hog cholera lapinized virus (HCLV), also called the "Chinese strain" or "C-strain" of classical swine fever virus (CSFV), was developed in China in the 1950s. There are uncertainties about the genetic heterogeneity and origin of this vaccine virus. The objectives of this study were to investigate the genetic heterogeneity of the C-strain, for which nucleotide sequences have been submitted to GenBank from different laboratories, and to determine whether there is any evidence to support the hypothesis that the C-strain originated from the Shimen strain. Analysis of 150 nearly complete E2 gene sequences revealed that the C-strain clade includes several HCLV vaccine strains, cell-culture-adapted Riems strains, and viruses isolated from diseased pigs. The whole-genome phylogeny indicated that the ancestor of the C-strain was only distantly related to the Shimen strain. Therefore, there was no phylogenetic evidence to support the Shimen-origin hypothesis.
中国猪霍乱兔化弱毒（HCLV），也被称为经典猪瘟病毒（CSFV）的“中国株”或“C 株”，是中国在 20 世纪 50 年代开发的。对于这种疫苗病毒的遗传异质性和起源存在不确定性。本研究的目的是调查 C 株的遗传异质性，因为不同实验室已经将其核苷酸序列提交给了 GenBank，并确定是否有任何证据支持 C 株起源于石门株的假设。对 150 个近乎完整的 E2 基因序列的分析表明，C 株进化枝包括几个 HCLV 疫苗株、细胞培养适应的 Riems 株以及从病猪中分离到的病毒。全基因组系统发育分析表明，C 株的祖先与石门株的关系非常疏远。因此，没有系统发育学证据支持石门起源假说。
