Giavazzi R, Garofalo A
LBTM, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy.
Methods Mol Med. 2001;58:223-9. doi: 10.1385/1-59259-137-X:223.
Animal studies are costly, time consuming, and subject to several restrictive regulations. However, the metastatic process is one of the research areas in which the in vivo studies remain most relevant (1). In fact, the in vitro studies are not fully predictive of the metastatic behavior of a tumor cell, probably because in vitro, it is difficult to reproduce the complexity of the metastatic process in itself and the interaction with the host.
动物研究成本高昂、耗时且受到多项严格规定的限制。然而，转移过程是体内研究仍然最为相关的研究领域之一（1）。事实上，体外研究并不能完全预测肿瘤细胞的转移行为，这可能是因为在体外难以重现转移过程本身的复杂性以及与宿主的相互作用。
