Tanashian M M, Ionova V G, Orlov S V, Omel'chenko N G, Shabalina A A, Kostyreva M V
Ter Arkh. 2010;82(10):19-24.
to study an association between metabolic syndrome and endothelial dysfunction as a regulator of hemorrheological and hemostatic processes in patients with chronic forms of cerebral circulatory insufficiency.
Forty-six patients with chronic cerebrovascular diseases (CCVD) were examined; of them 23 patients were diagnosed as having metabolic syndrome (MS). Clinical manifestations and major hemorrheological and hemostatic parameters, such as platelet and erythrocyte aggregation, fibrinogen, hematocrit, von Willebrand factor, antithrombin III, intercellular adhesion molecules (IAM), etc., were estimated. Endothelial dysfunction was studied from the data of cuff test (CT).
MS promotes a higher degree of clinical symptomatology in patients with CCVD and more significant impairments in the hemorrheological and hemostatic systems. CT has shown that all the patients have an inadequate endothelial reaction - the antiaggregatory, fibrinolytic, and anticoagulant activities of the endothelium are lowered. There was endothelium-dependent hyperproduction of IAM.
The found changes suggest that MS has a considerable impact on the formation of a significant procoagulant state of the hemorrheological and hemostatic systems in patients with CCVD.
研究慢性脑循环不全患者代谢综合征与内皮功能障碍之间的关联，内皮功能障碍作为血液流变学和止血过程的调节因子。
对46例慢性脑血管疾病（CCVD）患者进行检查；其中23例患者被诊断患有代谢综合征（MS）。评估临床表现以及主要血液流变学和止血参数，如血小板和红细胞聚集、纤维蛋白原、血细胞比容、血管性血友病因子、抗凝血酶III、细胞间黏附分子（IAM）等。根据袖带试验（CT）数据研究内皮功能障碍。
MS会使CCVD患者的临床症状更严重，血液流变学和止血系统的损害更显著。CT显示所有患者的内皮反应均不足——内皮的抗聚集、纤溶和抗凝活性降低。存在内皮依赖性的IAM过度产生。
所发现的变化表明，MS对CCVD患者血液流变学和止血系统显著促凝状态的形成有相当大的影响。
