[Identification of clinical features of cognitive impairment and depressive disorders in patients with metabolic syndrome with insufficiency of cerebral circulation].

Investigation involved 221 patients aged 50-84 with chronic insufficiency of cerebral circulation, who were divided into four groups: patients without metabolic syndrome (MS) and without depressive disorders (DD); subjects with MS without DD; subjects without MS with DD; subjects with MS with DD. All the patients also were divided into three subgroups depending on age. Patients with MS and DD and with MS without DD had significantly more vascular risk factors, comparing with other groups of patients. Mild cognitive impairment (CI) significantly more often were detected in patients without MS and without DD; dementia more often was observed in patients with MS and DD. Significant interrelationship between severity of CI and depression level was observed only in patients with MS. These data underline important role of MS as a risk factor of both DD and CI in patients with chronic insufficiency of cerebral circulation. Severity of DD significantly increased with age only in patients with MS. We observed significant growth of CI severity in all the groups of patients with increasing age. However stage of chronic insufficiency of cerebral circulation significantly influenced the severity of DD in patients with MS and without it.