Dorobăţ O, Leveneţ I, Paşolescu O, Lăzăroae D
Cantacuzino Institute, Bucharest, Romania.
Arch Roum Pathol Exp Microbiol. 1990 Jul-Sep;49(3):215-21.
499 N. meningitidis strains were studied, 454 being isolated from CSF and blood and 45 from nasopharynx. Meningococcal serogroup A was prevalent in 1986-1988, having a decreasing tendency from 84.90% in 1987 to 45.0% in 1989. Serogroup C increased from 0.86% in 1986 to 15% in 1989. All strains, examined by diffusiometric method, were sensitive to ampicillin, cephalotin, chloramphenicol and rifampin. For tetracycline, resistance ranged from 2.28 to 6.0% in 1987-1989. The frequency of 52.0-72.14% resistant to sulphamides strains seems to be due to serogroup A prevalence. Six N. meningitidis strains, isolated in 1989, proved to be moderately resistant to penicillin with MIC greater than or equal to 0.1 mcg/ml. The results indicate the necessity of a continuous surveillance of meningococcal infection, both from the point of view of serogroup circulation and also of antibiotics sensitivity.
对499株脑膜炎奈瑟菌进行了研究，其中454株从脑脊液和血液中分离得到，45株从鼻咽部分离得到。1986 - 1988年期间，A群脑膜炎球菌较为流行，从1987年的84.90%呈下降趋势至1989年的45.0%。C群从1986年的0.86%增至1989年的15%。采用扩散法检测的所有菌株对氨苄西林、头孢噻吩、氯霉素和利福平均敏感。1987 - 1989年期间，对四环素的耐药率在2.28%至6.0%之间。对磺胺类药物耐药菌株的频率为52.0 - 72.14%，这似乎是由于A群的流行所致。1989年分离出的6株脑膜炎奈瑟菌对青霉素表现为中度耐药，最低抑菌浓度大于或等于0.1微克/毫升。结果表明，从血清群流行情况以及抗生素敏感性角度来看，持续监测脑膜炎球菌感染很有必要。
