Passavanti Giandomenico
Department of Urology, Misericordia Hospital, Grosseto, Italy.
Arch Ital Urol Androl. 2010 Dec;82(4):173-6.
The basic principle of the hyperbaric oxygenation therapy (HOT) is to increase the dissolved oxygen in the blood when it is administered at high pressure. Then O2 will be distributed to the tissues through the pressure gradient, in this way obtaining an hyper-oxygenation of the tissue that has anti-inflammatory and pain-killing effects and induces augmentation of bacterial permeability to the antibiotics, neo-angiogenesis, enhancement of lymphocytes and macrophages function, augmentation of the testosterone secretion (in male), and healing of wound. These positive effects can be used in urology in several conditions: Scroto-perineal fascitis; Radiation-induced cystitis (and proctitis); Interstitial cystitis (urgency-frequency syndrome); Chronic pelvic pain. Our experience and the specific literature on this subject, suggest that HOT, sometimes associated with other medical and surgical therapies, can be a useful tool for treating such urologic diseases; in some cases this use is codified (Fournier's gangrene and Radiation-induced cystitis) in others (urgency-frequency syndrome and chronic pelvic pain) it represents a promising technique and needs further research.
高压氧疗法（HOT）的基本原理是在高压下给予治疗时增加血液中溶解的氧气。然后氧气将通过压力梯度分布到组织中，通过这种方式使组织获得超氧合状态，从而产生抗炎、止痛作用，并诱导细菌对抗生素的通透性增加、促进新血管生成、增强淋巴细胞和巨噬细胞功能、增加睾酮分泌（男性）以及促进伤口愈合。这些积极作用可在泌尿外科的多种病症中应用：阴囊 - 会阴筋膜炎；放射性膀胱炎（和直肠炎）；间质性膀胱炎（尿频 - 尿急综合征）；慢性盆腔疼痛。我们的经验以及关于该主题的特定文献表明，高压氧疗法有时与其他药物和手术疗法联合使用，可成为治疗此类泌尿系统疾病的有用工具；在某些情况下，这种应用已被规范（如Fournier坏疽和放射性膀胱炎），而在其他情况（尿频 - 尿急综合征和慢性盆腔疼痛）中，它是一种有前景的技术，需要进一步研究。
