Gandhi Jason, Seyam Omar, Smith Noel L, Joshi Gunjan, Vatsia Sohrab, Khan Sardar Ali
Department of Physiology and Biophysics, Stony Brook University School of Medicine, Stony Brook, NY, USA.
Medical Student Research Institute, St. George's University School of Medicine, Grenada, West Indies.
Med Gas Res. 2018 Apr 18;8(1):29-33. doi: 10.4103/2045-9912.229601. eCollection 2018 Jan-Mar.
Hyperbaric oxygen therapy (HBOT) is a medical technique which delivers oxygen at ambient pressures to increase the amount of dissolved oxygen in the blood and oxygen distribution to tissues. There are several beneficial properties of HBOT concomitant with elevated oxygen distribution in tissue including anti-inflammation, angiogenesis through vascular endothelial growth factor proliferation, augmented fibroblast activity through fibroblast growth factor proliferation, tissue and wound repair, enhancement of lymphocyte and macrophage activity, increased male testosterone secretion, and bactericidal activity. Given its renown in treating conditions such as decompression sickness and carbon monoxide poisoning, HBOT is making gradual strides for use in genitourinary medicine due to its low risk and likeliness to achieve favorable results. Early success has been observed in the treatment of Fournier's gangrene, radiation cystitis, and interstitial cystitis the elimination of clinical symptoms such as pain. Further indications that have exhibited positive outcomes despite HBOT's ambiguous mechanism of action include cyclophosphamide hemorrhagic cystitis, emphysematous cystitis, pelvic radiation disease, radiation-induced proctopathy, dystrophic calcification of the prostate, erectile dysfunction secondary to urethroplasty, priapism, abnormal renal morphology, blood testosterone, calcific uremic arteriolopathy, and hidradenitis suppurativa. For other indications, multicenter studies must be conducted to determine HBOT's true efficacy, mechanism of action, risks, and advantages over conventional treatments.
高压氧疗法（HBOT）是一种在环境压力下输送氧气以增加血液中溶解氧含量和氧气向组织分布的医学技术。HBOT伴随着组织中氧分布的增加具有多种有益特性，包括抗炎、通过血管内皮生长因子增殖促进血管生成、通过成纤维细胞生长因子增殖增强成纤维细胞活性、组织和伤口修复、增强淋巴细胞和巨噬细胞活性、增加男性睾酮分泌以及杀菌活性。鉴于其在治疗减压病和一氧化碳中毒等病症方面的声誉，HBOT因其低风险和可能取得良好效果而在泌尿生殖医学领域正逐步取得进展。在治疗福尼尔坏疽、放射性膀胱炎和间质性膀胱炎（消除疼痛等临床症状）方面已观察到早期成功。尽管HBOT的作用机制尚不明确，但已显示出积极结果的其他适应症包括环磷酰胺出血性膀胱炎、气肿性膀胱炎、盆腔放射病、放射性直肠病、前列腺营养不良性钙化、尿道成形术后继发的勃起功能障碍、阴茎异常勃起、肾脏形态异常、血睾酮、钙化性尿毒症小动脉病和化脓性汗腺炎。对于其他适应症，必须进行多中心研究以确定HBOT的真正疗效、作用机制、风险以及相对于传统治疗的优势。
