Department of Chemistry, The University of Western Ontario, 1151 Richmond Street, London, Ontario, N6A 5B7, Canada.
Org Lett. 2011 Mar 18;13(6):1528-31. doi: 10.1021/ol200220d. Epub 2011 Feb 22.
The formal [4+3] cycloaddition of 2-alkoxy-1,1-dicarboxylate activated donor-acceptor cyclobutanes with nitrones is disclosed. The reaction forms structurally unique oxazepines in moderate to high yield with a wide scope of nitrones. In most cases either a diastereomeric mixture or a single diastereomer may be formed, depending on the reaction conditions.
本文公开了 2-烷氧基-1,1-二羧酸酯活化的给体-受体环丁烷与硝酮的[4+3]环加成的正规反应。该反应以中等到高产率形成结构独特的恶唑嗪，具有广泛的硝酮范围。在大多数情况下，可能形成非对映异构体混合物或单个非对映异构体，这取决于反应条件。
