Sharma T N, Gulati R, Gupta P R, Goyal R L, Gupta S D, Bhatnagar M
Hospital for Chest and Tuberculosis, Jaipur.
Indian J Chest Dis Allied Sci. 1990 Oct-Dec;32(4):209-14.
The role of two calcium channel blockers, nifedipine and verapamil was investigated in patients of bronchial asthma. Both the drugs given orally produced an insignificant rise in PEFR, FEF25-75% and FEV1. Given along with terbutaline, however, these drugs produced significantly greater increase in PEFR, FEF25-75% and FEV1 as compared to patients receiving terbutaline alone. The two calcium channel blockers also inhibited the terbutaline induced tremors and palpitation.
研究了两种钙通道阻滞剂硝苯地平和维拉帕米在支气管哮喘患者中的作用。口服这两种药物后，呼气峰值流速（PEFR）、25%-75%用力呼气流量（FEF25-75%）和第一秒用力呼气容积（FEV1）仅有不显著的升高。然而，与单独接受特布他林治疗的患者相比，这两种药物与特布他林联合使用时，能使PEFR、FEF25-75%和FEV1有显著更大幅度的升高。这两种钙通道阻滞剂还能抑制特布他林引起的震颤和心悸。
