Department for Urology, University of Heidelberg, Heidelberg, Germany.
BJU Int. 2011 Oct;108(7):1192-7. doi: 10.1111/j.1464-410X.2010.10007.x. Epub 2011 Feb 22.
• To investigate the effect of different variables including body mass index (BMI) on therapy outcome in patients with upper urinary tract stones treated with a third generation lithotripter, as BMI has been reported to be an independent predictor for stone-free status after extracorporeal shockwave lithotripsy (SWL) performed with first or second generation lithotripters.
• In all, 172 patients with kidney stones with a mean (range) size of 9.2 (3.0-32.0) mm were included in the study. • In all, 91 patients (52.9%) were treated with a ureteric stent in situ. • For SWL therapy a third generation, electromagnetic lithotripter (Siemens Lithoskop™) was used. Stone-free status was reached, when no more treatable stones were present (no stone or stone < 3 mm). • BMI, stone size and localization, age, gender, treatment parameters and ureteric stent in situ were evaluated for their prognostic relevance on therapy success.
• The mean (range) BMI of all patients was 27.8 (19.0-58.6) kg/m(2). • Patients were categorized into two groups: A) patients that were stone free after one treatment; B) patients with residual stones. The mean (sd) BMI was 27.4 (4.6) kg/m(2) and 28.4 (6.1) kg/m(2) for A and B, respectively. • Univariate and multivariate analysis for freedom of stones showed that only stone size (P < 0.01) and presence of a ureteric stent (P = 0.01) were independent prognostic variables. • BMI had no significant influence on therapy outcome (P = 0.51).
• Using a third generation lithotripter, BMI was not an independent predictor of stone-free rate after SWL therapy of kidney stones. • This effect might be attributed to a greater penetration depth of the shockwave energy. Stone size and a ureteric stent in situ were the only variables with prognostic significance.
• 探讨包括体重指数(BMI)在内的不同变量对上尿路结石患者使用第三代碎石机治疗效果的影响,因为据报道BMI是使用第一代或第二代碎石机进行体外冲击波碎石术(SWL)后结石清除状态的独立预测指标。
• 本研究共纳入172例肾结石患者,结石平均(范围)大小为9.2(3.0 - 32.0)mm。• 共有91例患者(52.9%)在原位留置输尿管支架。• SWL治疗采用第三代电磁碎石机(西门子Lithoskop™)。当不再存在可治疗的结石(无结石或结石<3 mm)时达到结石清除状态。• 评估BMI、结石大小和位置、年龄、性别、治疗参数及原位输尿管支架对治疗成功的预后相关性。
• 所有患者的平均(范围)BMI为27.8(19.0 - 58.6)kg/m²。• 患者分为两组:A)单次治疗后结石清除的患者;B)有残余结石的患者。A组和B组的平均(标准差)BMI分别为27.4(4.6)kg/m²和28.4(6.1)kg/m²。• 结石清除的单因素和多因素分析显示,仅结石大小(P < 0.01)和输尿管支架的存在(P = 0.01)是独立的预后变量。• BMI对治疗效果无显著影响(P = 0.51)。
• 使用第三代碎石机时,BMI不是肾结石SWL治疗后结石清除率的独立预测指标。• 这种效应可能归因于冲击波能量的穿透深度更大。结石大小和原位输尿管支架是仅有的具有预后意义的变量。