Nussberger Fabio, Roth Beat, Metzger Tobias, Kiss Bernhard, Thalmann George N, Seiler Roland
Department of Urology, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.
Urolithiasis. 2017 Jun;45(3):317-321. doi: 10.1007/s00240-016-0915-4. Epub 2016 Aug 30.
The purpose of this study was to evaluate risk factors for renal hematoma after extracorporeal shock wave lithotripsy (SWL) for kidney stones in a matched case-control analysis of a subgroup of patients recruited from a prospective randomized cohort. Between 06/2010 and 03/2013, 418 patients underwent SWL with the MODULITH-SLX-F2-lithotripter for kidney stones. In 39/418 patients (9 %), ultrasound at post-treatment day 1 revealed renal hematomas. For 37 of these patients, a matched group without hematoma could be selected according to the following matching criteria: age, gender, number and energy of shock waves, stone burden and localization. Risk factors for renal hematoma after SWL were compared between the two groups. The rates of diabetes, stopped anticoagulant/antiplatelet medications and arterial hypertension were not different between the two groups (p > 0.2). The skin-kidney distance was virtually the same in both groups (p = 0.5). In the hematoma group, significantly more patients had a high (>30: n = 16) as well as a low (<21.5: n = 4) BMI when compared to the control group (n = 4; n = 0; p < 0.001). Importantly, all patients with BMI <21.5 developed renal hematomas after SWL. Patients with a high (>30) or low (<21.5) BMI had a higher risk for renal damage after SWL. Therefore, alternative endoscopic treatment options should be considered in these patients.
本研究的目的是,在一项对前瞻性随机队列中招募的患者亚组进行的配对病例对照分析中,评估体外冲击波碎石术(SWL)治疗肾结石后发生肾血肿的危险因素。2010年6月至2013年3月期间,418例患者使用MODULITH-SLX-F2型碎石机进行了肾结石SWL治疗。在418例患者中的39例(9%)中,治疗后第1天的超声检查显示有肾血肿。对于其中37例患者,可根据以下匹配标准选择无血肿的配对组:年龄、性别、冲击波次数和能量、结石负荷及位置。比较两组SWL后肾血肿的危险因素。两组之间的糖尿病、停用抗凝/抗血小板药物和动脉高血压发生率无差异(p>0.2)。两组的皮肤-肾脏距离基本相同(p=0.5)。与对照组相比,血肿组中BMI高(>30:n=16)以及BMI低(<21.5:n=4)的患者明显更多(对照组n=4;n=0;p<0.001)。重要的是,所有BMI<21.5的患者在SWL后均发生了肾血肿。BMI高(>30)或低(<21.5)的患者在SWL后发生肾损伤的风险更高。因此,对于这些患者应考虑其他内镜治疗选择。