• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[非小细胞肺癌中线粒体DNA含量的变化]

[Changes on mitochondrial DNA content in non-small cell lung cancer].

作者信息

Wang Hongmei, Dai Jigang

机构信息

Department of Thoracic Surgery, Xinqiao Hospital, Chongqing 400037, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2011 Feb;14(2):141-5. doi: 10.3779/j.issn.1009-3419.2011.02.07.

DOI:10.3779/j.issn.1009-3419.2011.02.07
PMID:21342645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5999772/
Abstract

BACKGROUND AND OBJECTIVE

It has been proven that the mitochondrial DNA (mtDNA) mutations and content change were associated with increasing risk of tumorigenesis. MtDNA content is significantly reduced in most substantive tumors. The aim of this study is to demonstrate whether mtDNA content is positively associated with non-small cell lung cancer (NSCLC) risk.

METHODS

MtDNA content in 37 matched lung carcinoma and histologically adjacent normal lung tissue samples from patients were analyzed by fluorogenic 5-nuclease real-time PCR techniques.

RESULTS

The mean copy number of mtDNA in lung carcinoma tissue samples was statistically lower than that in adjacent histologically normal lung tissue samples (P < 0.001).

CONCLUSIONS

The change of mtDNA content may play an important role in NSCLC.

摘要

背景与目的

已证实线粒体DNA（mtDNA）突变及含量变化与肿瘤发生风险增加相关。在大多数实体瘤中，mtDNA含量显著降低。本研究旨在证明mtDNA含量是否与非小细胞肺癌（NSCLC）风险呈正相关。

方法

采用荧光5-核酸酶实时PCR技术分析37例患者的肺癌组织及其组织学相邻正常肺组织样本中的mtDNA含量。

结果

肺癌组织样本中mtDNA的平均拷贝数在统计学上低于相邻组织学正常肺组织样本（P < 0.001）。

结论

mtDNA含量变化可能在NSCLC中起重要作用。

相似文献

1
[Changes on mitochondrial DNA content in non-small cell lung cancer].[非小细胞肺癌中线粒体DNA含量的变化]
Zhongguo Fei Ai Za Zhi. 2011 Feb;14(2):141-5. doi: 10.3779/j.issn.1009-3419.2011.02.07.
2
Mitochondrial genome microsatellite instability and copy number alteration in lung carcinomas.肺癌中线粒体基因组微卫星不稳定性及拷贝数改变
Asian Pac J Cancer Prev. 2013;14(4):2393-9. doi: 10.7314/apjcp.2013.14.4.2393.
3
Prognostic value of mitochondrial DNA content and G10398A polymorphism in non-small cell lung cancer.线粒体 DNA 含量和 G10398A 多态性在非小细胞肺癌中的预后价值。
Oncol Rep. 2013 Dec;30(6):3006-12. doi: 10.3892/or.2013.2783. Epub 2013 Oct 3.
4
Mitochondrial DNA 4977 BP deletion mutations in lung carcinoma.肺癌中的线粒体DNA 4977碱基对缺失突变
Indian J Cancer. 2006 Jan-Mar;43(1):20-5. doi: 10.4103/0019-509x.25771.
5
Following mitochondrial footprints through a long mucosal path to lung cancer.沿着线粒体的足迹，穿过漫长的黏膜途径到达肺癌。
PLoS One. 2009 Aug 6;4(8):e6533. doi: 10.1371/journal.pone.0006533.
6
Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study.前瞻性队列研究中线粒体 DNA 拷贝数与肺癌风险。
Carcinogenesis. 2010 May;31(5):847-9. doi: 10.1093/carcin/bgq045. Epub 2010 Feb 22.
7
Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer.线粒体 ND 基因中预测的致病性突变与 NSCLC 和结肠癌的远处转移相关。
Sci Rep. 2017 Nov 14;7(1):15535. doi: 10.1038/s41598-017-15592-2.
8
Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients.线粒体DNA拷贝数减少与中国乳腺癌患者的肿瘤进展及预后相关。
IUBMB Life. 2007 Jul;59(7):450-7. doi: 10.1080/15216540701509955.
9
MtDNA depletions and deletions may also be important in pathogenesis of lung cancer.线粒体DNA缺失和突变在肺癌发病机制中可能也很重要。
Respir Med. 2013 Nov;107(11):1814. doi: 10.1016/j.rmed.2013.04.024. Epub 2013 Aug 31.
10
Mitochondrial DNA copy number in colorectal cancer: between tissue comparisons, clinicopathological characteristics and survival.结直肠癌中的线粒体DNA拷贝数：组织比较、临床病理特征与生存情况之间的关系
Carcinogenesis. 2015 Dec;36(12):1502-10. doi: 10.1093/carcin/bgv151. Epub 2015 Oct 17.

引用本文的文献

1
Lung cancer increases HO concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa.肺癌会增加呼出气冷凝物中的羟基（HO）浓度、口腔黏膜中线粒体DNA（mtDNA）的损伤程度以及mtDNA拷贝数。
Heliyon. 2020 Jun 28;6(6):e04303. doi: 10.1016/j.heliyon.2020.e04303. eCollection 2020 Jun.

本文引用的文献

1
Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation.线粒体单链DNA结合蛋白是维持线粒体DNA和7S DNA所必需的，但对于线粒体类核组织并非必需。
Biochim Biophys Acta. 2010 Aug;1803(8):931-9. doi: 10.1016/j.bbamcr.2010.04.008. Epub 2010 Apr 28.
2
MTERF2 is a nucleoid component in mammalian mitochondria.线粒体转录终止因子2（MTERF2）是哺乳动物线粒体中的一种类核成分。
Biochim Biophys Acta. 2009 May;1787(5):296-302. doi: 10.1016/j.bbabio.2009.01.018. Epub 2009 Feb 3.
3
Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-kappaB activation and cell proliferation in human breast cancer MCF-7 cells.
亚砷酸钠可诱导人乳腺癌MCF-7细胞产生活性氧、造成DNA氧化损伤、增加血红素加氧酶-1（HO-1）和c-Myc蛋白表达、激活核因子κB（NF-κB）并促进细胞增殖。
Mutat Res. 2009 Mar 31;674(1-2):109-15. doi: 10.1016/j.mrgentox.2008.09.021. Epub 2008 Oct 18.
4
DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway.DNA损伤和内质网应激通过激活半胱天冬酶级联反应和线粒体依赖性途径介导姜黄素诱导人肺癌A-549细胞的细胞周期阻滞和凋亡。
Cancer Lett. 2008 Dec 8;272(1):77-90. doi: 10.1016/j.canlet.2008.06.031. Epub 2008 Aug 12.
5
Mitochondrial DNA content and lung cancer risk in Xuan Wei, China.中国宣威地区的线粒体DNA含量与肺癌风险
Lung Cancer. 2009 Mar;63(3):331-4. doi: 10.1016/j.lungcan.2008.06.012. Epub 2008 Aug 8.
6
Mitochondrial haplogroup T is negatively associated with the status of elite endurance athlete.线粒体单倍群T与优秀耐力运动员的状态呈负相关。
Mitochondrion. 2007 Sep;7(5):354-7. doi: 10.1016/j.mito.2007.06.002. Epub 2007 Jun 27.
7
Application of mitochondrial genome information in cancer epidemiology.线粒体基因组信息在癌症流行病学中的应用。
Clin Chim Acta. 2007 Aug;383(1-2):41-50. doi: 10.1016/j.cca.2007.04.018. Epub 2007 Apr 30.
8
Depletion of mitochondrial DNA by down-regulation of deoxyguanosine kinase expression in non-proliferating HeLa cells.通过下调非增殖性HeLa细胞中脱氧鸟苷激酶的表达来消耗线粒体DNA。
Exp Cell Res. 2007 Jul 15;313(12):2687-94. doi: 10.1016/j.yexcr.2007.04.003. Epub 2007 Apr 6.
9
Tumor-specific changes in mtDNA content in human cancer.人类癌症中线粒体DNA含量的肿瘤特异性变化。
Int J Cancer. 2005 Oct 10;116(6):920-4. doi: 10.1002/ijc.21110.
10
Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma.人类肝细胞癌中线粒体DNA的拷贝数改变与缺失
Br J Cancer. 2004 Jun 14;90(12):2390-6. doi: 10.1038/sj.bjc.6601838.