Epidemic Intelligence Service, Office of Workforce and Career Development assigned to Influenza Division, Centers for DiseaseControl and Prevention, Atlanta, Georgia, USA.
Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S69-74. doi: 10.1093/cid/ciq011.
The 2009 pandemic influenza A (H1N1) (pH1N1) virus emerged in the United States in April 2009 (1) and has since caused significant morbidity and mortality worldwide (2-6). We compared pandemic influenza A (H1N1) (pH1N1)-associated deaths occurring from 15 April 2009 through 23 January 2010 with seasonal influenza-associated deaths occurring from 1 October 2007 through 14 April 2009, a period during which data collected were most comparable. Among 317 children who died of pH1N1-associated illness, 301 (95%) had a reported medical history. Of those 301, 205 (68%) had a medical condition associated with an increased risk of severe illness from influenza. Children who died of pH1N1-associated illness had a higher median age (9.4 vs 6.2 years; P<.01) and longer time from onset of symptoms to death (7 vs 5 days, P<.01) compared with children who died of seasonal influenza-associated illness. The majority of pediatric deaths from pH1N1 were in older children with high-risk medical conditions. Vaccination continues to be critical for all children, especially those at increased risk of influenza-related complications.
2009 年甲型 H1N1 流感（pH1N1）病毒于 2009 年 4 月在美国出现（1），此后在全球范围内造成了大量的发病率和死亡率（2-6）。我们将 2009 年 4 月 15 日至 2010 年 1 月 23 日期间发生的甲型 H1N1（pH1N1）相关死亡病例与 2007 年 10 月 1 日至 2009 年 4 月 14 日期间发生的季节性流感相关死亡病例进行了比较，这是数据最可比的时期。在 317 名死于 pH1N1 相关疾病的儿童中，有 301 名（95%）有报告的病史。在这 301 名儿童中，有 205 名（68%）有与流感相关的严重疾病风险增加的医疗状况。与死于季节性流感相关疾病的儿童相比，死于 pH1N1 相关疾病的儿童的中位年龄更高（9.4 岁比 6.2 岁；P<.01），从发病到死亡的时间也更长（7 天比 5 天，P<.01）。大多数死于 pH1N1 的儿科病例发生在有高风险医疗状况的大龄儿童中。疫苗接种仍然对所有儿童，特别是那些有流感相关并发症风险增加的儿童至关重要。
