Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave., Davis, CA 95661-8645, USA.
Infect Immun. 2011 May;79(5):1806-14. doi: 10.1128/IAI.01369-10. Epub 2011 Feb 22.
Salmonella serotypes are a major cause of human morbidity and mortality worldwide. Over the past decades, a series of animal models have been developed to advance vaccine development, provide insights into immunity to infection, and study the pathogenesis of human Salmonella disease. The successive introduction of new animal models, each suited to interrogate previously neglected aspects of Salmonella disease, has ushered in important conceptual advances that continue to have a strong and sustained influence on the ideas driving research on Salmonella serotypes. This article reviews important milestones in the use of animal models to study human Salmonella disease and identify research needs to guide future work.
沙门氏菌血清型是全球导致人类发病率和死亡率的主要原因。在过去几十年中，已经开发出一系列动物模型来推进疫苗开发，深入了解感染免疫，并研究人类沙门氏菌病的发病机制。随着新的动物模型的相继引入，每个模型都适合研究以前被忽视的沙门氏菌病方面，这带来了重要的概念性进展，这些进展继续对推动沙门氏菌血清型研究的理念产生强烈而持久的影响。本文回顾了使用动物模型研究人类沙门氏菌病的重要里程碑，并确定了指导未来工作的研究需求。
