微生物简介：鼠伤寒沙门氏菌：适应之术的大师。
Microbe Profile: Typhimurium: the master of the art of adaptation.
作者信息
Perez-Sepulveda Blanca M, Hinton Jay C D
机构信息
Clinical Infection, Microbiology & Immunology Department, Institute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, UK.
出版信息
Microbiology (Reading). 2025 Jan;171(1). doi: 10.1099/mic.0.001521.
Abstract
Typhimurium is a major serovar that is found globally. It is responsible for outbreaks of self-limiting gastroenteritis that are broadly linked to the industrialization of food production. . Typhimurium is a pathogen with a broad host range and remarkable metabolic versatility. The ∼5 Mb genome includes the pSLT virulence plasmid and has a characteristic prophage repertoire. The major virulence determinants are encoded by a variety of pathogenicity islands. Emerging multidrug-resistant lineages of epidemics of . Typhimurium are currently causing bloodstream infections in sub-Saharan Africa. The versatility and adaptability of . Typhimurium pose an important public health challenge.
摘要
鼠伤寒沙门氏菌是一种在全球范围内都能发现的主要血清型。它是导致自限性肠胃炎暴发的原因，这些暴发与食品生产工业化广泛相关。鼠伤寒沙门氏菌是一种宿主范围广泛且代谢具有显著多样性的病原体。约5兆碱基的基因组包含pSLT毒力质粒，并具有特征性的前噬菌体库。主要的毒力决定因素由多种致病岛编码。鼠伤寒沙门氏菌新出现的多重耐药流行谱系目前正在撒哈拉以南非洲地区引发血流感染。鼠伤寒沙门氏菌的多样性和适应性构成了一项重要的公共卫生挑战。
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