Doi K, Honjo K, Doi C, Mitsuoka T
Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Japan.
Histol Histopathol. 1990 Apr;5(2):139-43.
Effects of cyclophosphamide (CY) on the antibody titer level and incidence and severity of swine serum (SS)-induced bile duct lesion (BDL) were examined. BDL induced by 0.2 ml of SS per head twice a week for 2 weeks was characterized by hyperplasia of biliary epithelial cells, proliferation of mucous glands, and periductal infiltration of eosinophils with mild fibrosis. CY showed no significant influence on the above-mentioned parameters at the dose levels of 140 and 210 mg/kg. On the other hand, CY lowered the antibody titer level and decreased the severity of BDL at the dose level of 280 mg/kg, and it suppressed the antibody response and BDL at the dose level of 280 x 2 mg/kg. Thus the antibody titer level and the severity of BDL were closely related each other.
研究了环磷酰胺（CY）对猪血清（SS）诱导的胆管病变（BDL）的抗体滴度水平以及发病率和严重程度的影响。每周两次，每次每头猪注射0.2 ml SS，持续2周诱导产生的BDL的特征为胆管上皮细胞增生、黏液腺增殖以及嗜酸性粒细胞在导管周围浸润并伴有轻度纤维化。在140和210 mg/kg的剂量水平下，CY对上述参数无显著影响。另一方面，在280 mg/kg的剂量水平下，CY降低了抗体滴度水平并减轻了BDL的严重程度，在280×2 mg/kg的剂量水平下，CY抑制了抗体反应和BDL。因此，抗体滴度水平与BDL的严重程度密切相关。
