Imaoka K, Doi K, Doi C, Toriumi W, Honjo K, Mitsuoka T
Lab Anim. 1986 Oct;20(4):321-4. doi: 10.1258/002367786780808686.
The mouse strain difference in bile duct lesions was studied on male A/J, BALB/c, C57BL/6, C3H/He, DBA/2 and DDY mice 4 weeks old given intraperitoneal injections of swine serum (0.05 or 0.2 ml per mouse) twice a week for 4 weeks. The hepatic lesions were restricted to the portal tract. Biliary epithelial cells showed hypertrophy and hyperplasia, and eosinophilic and homogeneous or needle-shaped material appeared in the cytoplasm of such hypertrophied epithelial cells and in the ductular lumen. Around these damaged biliary epithelia, eosinophil leukocyte and plasma cell infiltration with proliferation of collagen fibres was commonly detected. These changes became more apparent with increasing size of bile duct. Such histopathological characteristics of hepatic lesions were essentially the same in all strains, but the severity showed a clear strain difference: the lesion was marked in the DDY, A/J and BALB/c strains, moderate in C3H/He and slight in C57BL/6 and DBA/2. A high production of anti-swine-serum antibodies associated with a marked increase in the number of mouse IgG-producing lymphocytes in the spleen was detected in the strains showing the marked hepatic lesions.
对4周龄雄性A/J、BALB/c、C57BL/6、C3H/He、DBA/2和DDY小鼠进行研究，每周两次腹腔注射猪血清（每只小鼠0.05或0.2 ml），持续4周，观察胆管病变的小鼠品系差异。肝脏病变局限于门管区。胆管上皮细胞出现肥大和增生，在这些肥大的上皮细胞胞质和小胆管腔内出现嗜酸性、均质或针状物质。在这些受损胆管上皮周围，常见嗜酸性白细胞和浆细胞浸润以及胶原纤维增生。随着胆管管径增大，这些变化更加明显。所有品系肝脏病变的组织病理学特征基本相同，但严重程度存在明显的品系差异：DDY、A/J和BALB/c品系病变明显，C3H/He品系病变中等，C57BL/6和DBA/2品系病变轻微。在肝脏病变明显的品系中，检测到与脾脏中产生小鼠IgG的淋巴细胞数量显著增加相关的抗猪血清抗体的高产量。
