Breast Cancer Res. 2011 Feb 1;13(1):104. doi: 10.1186/bcr2807.
Implementation of high-throughput genomics sequencing approaches into routine laboratory practice has raised the potential for the identification of multiple breast cancer targets suitable for future therapeutic intervention in order to improve cancer outcomes. Results from these studies have revealed bewildering breast cancer genome complexity with very few aberrations occurring in common between breast cancers. In addition, such complexity is compounded by evidence of genomic heterogeneity occurring within individual breast cancers. Such inter-tumoural and intratumoural heterogeneity is likely to present a challenge to personalised therapeutic approaches that might be circumvented through the definition of genome instability mechanisms governing such diversity and their exploitation using synthetic lethal approaches.
高通量基因组测序方法在常规实验室实践中的应用，提高了鉴定多个乳腺癌靶标以用于未来治疗干预的潜力，从而改善癌症预后。这些研究的结果揭示了令人困惑的乳腺癌基因组复杂性，在乳腺癌之间很少有常见的异常。此外，这种复杂性因个体乳腺癌中存在的基因组异质性的证据而加剧。这种肿瘤间和肿瘤内异质性可能对个性化治疗方法构成挑战，通过定义控制这种多样性的基因组不稳定性机制及其使用合成致死方法加以利用，可能会规避这些挑战。
