Equipe de RMN en milieu orienté, ICMMO, UMR 8182 CNRS Univ Paris-Sud 11, bât 410, 91405 Orsay cedex, France.
J Magn Reson. 2011 Apr;209(2):315-22. doi: 10.1016/j.jmr.2011.01.030. Epub 2011 Feb 3.
The application of the G-SERFph pulse sequence is presented on enantiomeric mixtures dissolved in a chiral liquid crystal. It aims at editing, within one single 2D spectrum, every proton coupling which is experienced by a given proton site in the molecule, and leads to real phased T-edited spectroscopy (T=J+2D). This NMR experiment is based on the combination of homonuclear semi-selective refocusing techniques with a spatial frequency encoding of the sample. This approach, which consists in handling selectively each coupling in separate cross sections of the sample, is applied to the visualization of enantiomers dissolved in a chiral liquid crystalline phase. Advantages and limits of this methodology are widely discussed.
本文介绍了 G-SERFph 脉冲序列在手性液晶溶液中对映异构体混合物的应用。该序列的目的是在单个二维谱中编辑分子中每个质子所处的特定质子位置的所有质子偶合，从而得到真正的相位 T 编辑光谱（T=J+2D）。该 NMR 实验基于同核半选择性重聚焦技术与样品空间频率编码的组合。该方法通过选择性地处理样品各截面中的每个耦合来实现，可用于手性液晶相溶解的对映异构体的可视化。本文广泛讨论了这种方法的优缺点。
