Davenport D
Mark Morris Associates, Topeka, KS 66049.
Probl Vet Med. 1990 Jun;2(2):374-93.
Antimicrobials are a common part of a symptomatic approach to the treatment of gastrointestinal disorders. Without an etiologic diagnosis, antimicrobial therapy is likely to be of little value and, in the worst case, may harm the patient either by altering normal gastrointestinal flora or by producing direct toxicity. This review is a systematic appraisal of antimicrobial therapy for gastrointestinal disease, beginning with the oral cavity, proceeding through the gastrointestinal tract and concluding with pancreatic and hepatic disorders. The intent is to highlight specific etiologies which form the basis for rational therapeutic choices. Controversies concerning the need for antimicrobial therapy or therapeutic alternatives are also explored. The review concludes with a discussion of adverse gastrointestinal effects of antimicrobial therapy.
抗菌药物是胃肠道疾病对症治疗中常用的一部分。在没有病因诊断的情况下，抗菌治疗可能价值不大，而且在最坏的情况下，可能会因改变正常胃肠道菌群或产生直接毒性而对患者造成伤害。本综述是对抗菌治疗胃肠道疾病的系统评估，从口腔开始，贯穿胃肠道，最后是胰腺和肝脏疾病。目的是突出构成合理治疗选择基础的特定病因。还探讨了有关抗菌治疗必要性或治疗替代方案的争议。综述最后讨论了抗菌治疗的胃肠道不良反应。
