Veterans Affairs Medical Center, GRECC 11G, One Veterans Drive, Minneapolis, MN, USA.
Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1053-69. doi: 10.1152/ajpregu.00776.2010. Epub 2011 Feb 23.
Brain-derived neurotrophic factor (BDNF) mediates energy metabolism and feeding behavior. As a neurotrophin, BDNF promotes neuronal differentiation, survival during early development, adult neurogenesis, and neural plasticity; thus, there is the potential that BDNF could modify circuits important to eating behavior and energy expenditure. The possibility that "faulty" circuits could be remodeled by BDNF is an exciting concept for new therapies for obesity and eating disorders. In the hypothalamus, BDNF and its receptor, tropomyosin-related kinase B (TrkB), are extensively expressed in areas associated with feeding and metabolism. Hypothalamic BDNF and TrkB appear to inhibit food intake and increase energy expenditure, leading to negative energy balance. In the hippocampus, the involvement of BDNF in neural plasticity and neurogenesis is important to learning and memory, but less is known about how BDNF participates in energy homeostasis. We review current research about BDNF in specific brain locations related to energy balance, environmental, and behavioral influences on BDNF expression and the possibility that BDNF may influence energy homeostasis via its role in neurogenesis and neural plasticity.
脑源性神经营养因子（BDNF）介导能量代谢和摄食行为。作为一种神经营养因子，BDNF 促进神经元分化、早期发育中的存活、成年神经发生和神经可塑性；因此，BDNF 有可能改变与摄食行为和能量消耗有关的电路。BDNF 可以重塑“有缺陷”的电路，这是肥胖和饮食失调新疗法的一个令人兴奋的概念。在下丘脑，BDNF 和其受体原肌球蛋白相关激酶 B（TrkB）广泛表达于与摄食和代谢相关的区域。下丘脑 BDNF 和 TrkB 似乎抑制食物摄入并增加能量消耗，导致负能平衡。在海马体中，BDNF 在神经可塑性和神经发生中的参与对学习和记忆很重要，但关于 BDNF 如何参与能量稳态的了解较少。我们综述了与能量平衡相关的特定脑区中 BDNF 的最新研究，以及环境和行为对 BDNF 表达的影响，以及 BDNF 可能通过其在神经发生和神经可塑性中的作用影响能量稳态的可能性。
