探讨脑源性神经营养因子在摄食行为的中枢调控中的作用。
Weighing in the role of BDNF in the central control of eating behavior.
机构信息
Department of Neuroscience and Program in Neuroscience, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
出版信息
Mol Neurobiol. 2011 Dec;44(3):441-8. doi: 10.1007/s12035-011-8212-2. Epub 2011 Oct 20.
Abstract
The prevalence of obesity and its associated medical complications, including type 2 diabetes and cardiovascular disease, continues to rise globally. Lifestyle changes in the last decades have greatly contributed to the current obesity trends. However, inheritable biological factors that disrupt the tightly regulated equilibrium between caloric intake and energy expenditure also appear to play a critical part. Mounting evidence obtained from human and rodent studies suggests that perturbed brain-derived neurotrophic factor (BDNF) signaling in appetite-regulating centers in the brain might be a culprit. Here, we review findings that inform the critical roles of BDNF and its receptor TrkB in energy balance and reward centers of the brain impacting feeding behavior and body weight.
摘要
肥胖及其相关的医学并发症（包括 2 型糖尿病和心血管疾病）的患病率在全球范围内持续上升。过去几十年的生活方式改变极大地促成了当前的肥胖趋势。然而，扰乱热量摄入和能量消耗之间的严格调节平衡的可遗传生物因素似乎也起着至关重要的作用。从人类和啮齿动物研究中获得的越来越多的证据表明，大脑中调节食欲的中心中紊乱的脑源性神经营养因子（BDNF）信号可能是罪魁祸首。在这里，我们回顾了 BDNF 及其受体 TrkB 在大脑的能量平衡和奖励中心中的关键作用的发现，这些作用影响进食行为和体重。
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