Oculoplastic and Paediatric Ophthalmology Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Ophthalmic Plast Reconstr Surg. 2011 Nov-Dec;27(6):e167-8. doi: 10.1097/IOP.0b013e31820ccb13.
A 26-year-old man had a history of multiple nodules involving the upper and lower eyelids bilaterally, for which he had undergone wide local excision along with eyelid reconstruction. Three years later, he presented to the authors with recurrence of the tumor masses. Tumor debulking surgery was performed bilaterally, with eyelid reconstructive surgery. Histopathology of the excised mass showed spindle-shaped cells in the dermis, which were arranged in a storiform pattern. Immunohistochemically, the tumor expressed vimentin diffusely and CD-34 focally. Histopathologic findings of storiform pattern of tumor cells and positive immunohistochemical stains for CD-34 led to the diagnosis of dermatofibrosarcoma protuberans. The clinical course was marked by repeated local recurrences following multiple debulking procedures. Local control could not be achieved in this case and at last follow up, the tumor was surgically unresectable.
一位 26 岁男性患者双侧上、下眼睑有多个结节，曾行广泛局部切除术联合眼睑重建术。3 年后，患者因肿瘤复发就诊。行双侧肿瘤切除术及眼睑重建术。切除肿块的组织病理学检查显示真皮内有梭形细胞，呈席纹状排列。免疫组化检查显示肿瘤弥漫表达波形蛋白，局灶性表达 CD-34。梭形肿瘤细胞的组织病理学表现和 CD-34 的免疫组化阳性染色诊断为隆突性皮肤纤维肉瘤。该患者在多次减瘤手术后出现反复局部复发，局部控制不理想。在最后一次随访时，肿瘤无法手术切除。
