Department of Cardiological, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
Panminerva Med. 2011 Mar;53(1):13-8.
The aims of this study were: 1) to quantify endothelial function by flow-mediated dilation (FMD) and atherosclerotic vascular lesions by intima-media thickness (IMT) in migraine sufferers without any of the common atherosclerotic risk factors, comparing them with paired controls; 2) to evaluate their potential autonomic function impairment; and 3) to seek any correlations with vascular modifications.
Twenty patients suffering from migraine and 20 matched controls were studied, using echo-color-Doppler imaging to measure IMT in the carotid district and FMD of the brachial artery in the non-dominant arm. Autonomic function was studied using the Tilt, Lying-to-Standing, Valsalva, Hand grip, Deep breath, Stroop and Sweat tests.
Migraine sufferers had lower FMD and higher IMT values than controls. The former also had autonomic changes revealed by the Tilt, Valsalva, Hand Grip, Deep Breath and Stroop tests, which correlated with their reduced FMD.
Autonomic dysfunctions modify vascular reactivity in migraine sufferers and this type of change can probably determine endothelial dysfunction and intima-media thickening.
本研究的目的是：1）通过血流介导的扩张（FMD）量化偏头痛患者的内皮功能，并通过内膜中层厚度（IMT）量化动脉粥样硬化血管病变，将其与配对对照组进行比较；2）评估他们潜在的自主功能障碍；3）寻找与血管改变的任何相关性。
使用超声彩色多普勒成像测量颈动脉区 IMT 和非优势臂肱动脉 FMD，研究 20 例偏头痛患者和 20 例匹配对照者。使用倾斜、卧位到站立位、瓦尔萨尔瓦、握力、深呼吸、斯特鲁普和汗液测试研究自主功能。
偏头痛患者的 FMD 低于对照组，IMT 值高于对照组。前者还存在自主神经改变，表现为倾斜、瓦尔萨尔瓦、握力、深呼吸和斯特鲁普测试异常，这与其 FMD 降低有关。
自主神经功能障碍改变偏头痛患者的血管反应性，这种类型的改变可能会导致内皮功能障碍和内膜中层增厚。
