Mishra Akaash Kumar, Jain Chakresh Kumar, Agrawal Apurva, Jain Saransh Jain Kumar Sambhav, Dudha Namrata, Kumar Kapila, Sharma Sanjeev K, Gupta Sanjay
Department of Biotechnology, Jaypee Institute of Information Technology, NOIDA 201307, India.
Bioinformation. 2010 Jun 5;5(1):4-6. doi: 10.6026/97320630005004.
In the recent past, there has been a resurgence of interest in Chikungunya virus (CHIKV) attributed to massive outbreaks of Chikungunya fever in the South-East Asia Region. This has reflected in substantial increase in submission of CHIKV genome sequences to NCBI (National Center for Biotechnology Information) database. Hereby we submit a database "CHIKVPRO" containing structural and functional annotation of Chikungunya virus proteins (25 strains) submitted in the NCBI repository. The CHIKV genome encodes for 9 proteins:4 non-structural and 5 structural. The CHIKVPRO database aims to provide the virology community with a single accession authoritative resource for CHIKV proteome- with reference to physiochemical and molecular properties, proteolytic cleavage sites, hydrophobicity, transmembrane prediction, and classification into functional families using SVMProt and other Expasy tools.
The database is freely available at http://www.chikvpro.info/
最近，由于东南亚地区基孔肯雅热的大规模爆发，人们对基孔肯雅病毒（CHIKV）的兴趣再度兴起。这反映在向NCBI（美国国立生物技术信息中心）数据库提交的CHIKV基因组序列大幅增加。在此，我们提交一个名为“CHIKVPRO”的数据库，其中包含提交至NCBI数据库的基孔肯雅病毒蛋白（25个毒株）的结构和功能注释。CHIKV基因组编码9种蛋白：4种非结构蛋白和5种结构蛋白。CHIKVPRO数据库旨在为病毒学界提供一个关于CHIKV蛋白质组的单一权威资源库，内容涉及物理化学和分子特性、蛋白水解切割位点、疏水性、跨膜预测，以及使用SVMProt和其他Expasy工具将其分类为功能家族。
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