Departments of Neurosurgery and Internal Medicine, University of Texas Health Sciences Center at Houston Medical School, 6431 Fannin Street, MSB 7.154, Houston, TX 77030, USA.
Neurocrit Care. 2011 Jun;14(3):482-8. doi: 10.1007/s12028-011-9513-z.
Hypoalbuminemia is common among critically ill/injured patients and is strongly associated with increased morbidity and mortality in the patients with and without neurological conditions. Normal serum albumin is important as the primary intravascular antioxidant, in transporting a variety of hormones, medications and electrolytes, in providing colloid osmotic pressure during trans-compartmental fluid movement, in enhancing organ and tissue blood flow, and in supporting acid-base balance. Studies of albumin administration during intravascular resuscitation have not addressed potential longer term benefits to sustaining serum albumin concentrations during critical care. Evidence for such benefit is present although additional prospective studies are needed.
低蛋白血症在危重症/创伤患者中很常见，与有或无神经系统疾病的患者的发病率和死亡率增加密切相关。正常的血清白蛋白作为主要的血管内抗氧化剂很重要，它可以运输各种激素、药物和电解质，在跨室体液运动过程中提供胶体渗透压，增强器官和组织的血流，并支持酸碱平衡。血管内复苏期间白蛋白给药的研究尚未解决在重症监护期间维持血清白蛋白浓度的潜在长期益处。尽管需要进一步的前瞻性研究，但这种益处的证据是存在的。
