神经危重症中的抗氧化策略。
Antioxidant strategies in neurocritical care.
机构信息
Department of Neurology, Divisions of Neurocritical Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
出版信息
Neurotherapeutics. 2012 Jan;9(1):44-55. doi: 10.1007/s13311-011-0085-6.
Abstract
An increase in oxidative stress and overproduction of oxidizing reactive species plays an important role in the pathophysiology of several conditions encountered in the neurocritical care setting including: ischemic and hemorrhagic strokes, traumatic brain injury, acute respiratory distress syndrome, sepsis, and organ failure. The presence of oxidative stress in these conditions is supported by a large body of pre-clinical and clinical studies, and provides a rationale to support a potential therapeutic role for antioxidants. The purpose of this article is to briefly review the basic mechanisms and molecular biology of oxidative stress, summarize its role in critically ill neurological patients, and review available data regarding the potential role of antioxidant strategies in neurocritical care and future directions.
摘要
氧化应激和氧化反应性物质的过度产生增加在神经危重病护理环境中遇到的几种情况的病理生理学中起着重要作用，包括：缺血性和出血性中风、创伤性脑损伤、急性呼吸窘迫综合征、脓毒症和器官衰竭。大量的临床前和临床研究支持这些情况下存在氧化应激，为抗氧化剂的潜在治疗作用提供了依据。本文的目的是简要回顾氧化应激的基本机制和分子生物学，总结其在重症神经患者中的作用，并综述抗氧化策略在神经危重病护理中的潜在作用及未来方向的现有数据。
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