Sánchez-Lara Karla, Morales-Graf Laura, Green Dan, Sosa-Sánchez Ricardo, Méndez-Sánchez Nahum
Centro Oncológico Integral Diana Laura Riojas de Colosio, Fundación Clínica Médica Sur, México D.F., México.
Gac Med Mex. 2010 Sep-Oct;146(5):326-31.
The prevalence of obesity is increasing worldwide. Obesity is also a major risk factor for developing chronic diseases, including malignancies thereby increasing the risk of several types of tumors such as breast, endometrium, colon, prostate and kidney cancer. The mechanisms associated with obesity and insulin resistance, hormonal regulation and other proinflammatory factors are also involved in neoplastic processes including: cell proliferation, carcinogenesis, and angiogenesis vascularization. In addition to contributing to cancer pathogenesis obesity is associated with comorbidities and poor prognosis in cancer patients. The aim of this review is to describe some of the mechanisms involved in the association of obesity and malignancies.
