State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
Org Biomol Chem. 2011 May 7;9(9):3133-5. doi: 10.1039/c0ob01208d. Epub 2011 Mar 21.
A concise and efficient synthesis of benzo[c]phenanthridines was accomplished by the palladium-catalyzed ring-opening coupling of azabicyclic alkene with o-iodobenzoates, followed by tandem cyclization. The strategy was successfully applied in the total synthesis of benzo[c]phenanthridine alkaloids such as sanguinarine, chelerythrine, nitidine and avicine.
通过钯催化的氮杂环烯烃与邻碘苯甲酸酯的开环偶联，随后串联环化，实现了苯并[c]菲啶的简洁高效合成。该策略成功应用于苯并[c]菲啶生物碱如血根碱、白屈菜红碱、尼定碱和阿魏宁的全合成。
