Department of Medicine, L.R. Strelitz Diabetes Center for Endocrinology and Metabolism, L.R. Strelitz Diabetes Research Institute, Eastern Virginia Medical School, 855 West Brambleton Boulevard, Norfolk, VA 23510, USA.
Endocrinol Metab Clin North Am. 2011 Mar;40(1):81-96, viii. doi: 10.1016/j.ecl.2010.12.009.
Obesity is a disease state with polygenic inheritance, the phenotypic penetrance of which has been greatly expanded by the attributes of modern civilization. More than two-thirds of obese persons have comorbidities, many of which are characteristic of cardiometabolic risk syndrome (CMRS) in addition to other life-quality-reducing complaints. The CMRS is associated with increased cardiovascular events and mortality. Individuals with a body mass index greater than 35 infrequently achieve or maintain weight loss adequate to resolve these metabolic and anatomic issues by lifestyle or pharmacologic strategies. Data suggest that some of these patients may be better served by bariatric surgery.
肥胖是一种具有多基因遗传的疾病状态，其表型外显率已被现代文明的特征大大扩展。超过三分之二的肥胖者存在合并症，其中许多除了其他降低生活质量的抱怨外，还具有心血管代谢风险综合征 (CMRS) 的特征。CMRS 与心血管事件和死亡率的增加有关。身体质量指数大于 35 的个体很少通过生活方式或药物策略实现或维持足以解决这些代谢和解剖问题的体重减轻。数据表明，对于其中一些患者，减重手术可能更有帮助。
