颈动脉壁厚度与脑白质疏松症：多排 CT 血管造影的初步结果。
Carotid artery wall thickness and leukoaraiosis: preliminary results using multidetector row CT angiography.
机构信息
Department of Radiology, Azienda Ospedaliero Universitaria Cagliari, Italy.
出版信息
AJNR Am J Neuroradiol. 2011 May;32(5):955-61. doi: 10.3174/ajnr.A2396. Epub 2011 Feb 24.
BACKGROUND AND PURPOSE
LA is a condition caused by chronic cerebral ischemia and it represents an independent risk for stroke. The purpose of this work was to determine whether CAWT studied by using MDCTA is correlated with LA and its severity.
MATERIALS AND METHODS
Ninety-eight patients ≥60 years of age were retrospectively studied by using multidetector row CT. Supra-aortic vessel analysis and brain CT were performed in the same procedure. In each patient, CAWT was measured with an internal digital caliper, and the presence and severity of LA were assessed. Correlation coefficients by using Spearman statistics and ROC curves were calculated. A P value < .05 was considered statistically significant.
RESULTS
Measurements of the distal common CAWT ranged from 0.5 to 1.53 mm. A correlation between LA and increased CAWT was observed (Pearson correlation, 0.33; P < .001). On the basis of a threshold of 0.9 mm, an important statistical association between increased CAWT and LA (P < .0001) was found. With the same threshold, ROC curve analysis indicated a sensitivity of 55% and a specificity of 75% for LA.
CONCLUSIONS
The results of this study show a statistically significant correlation between increased CAWT and LA (and its severity).
背景与目的
LA 是由慢性脑缺血引起的一种病症，它是中风的一个独立危险因素。本研究旨在确定使用 MDCTA 研究的 CAWT 是否与 LA 及其严重程度相关。
材料与方法
对 98 名年龄≥60 岁的患者进行了回顾性多排 CT 研究。在同一程序中进行了升主动脉血管分析和脑 CT。在每个患者中，使用内部数字卡尺测量 CAWT，并评估 LA 的存在和严重程度。使用 Spearman 统计和 ROC 曲线计算相关系数。P 值<.05 被认为具有统计学意义。
结果
远端颈总动脉 CAWT 的测量值范围为 0.5 至 1.53 毫米。观察到 LA 与 CAWT 增加之间存在相关性（Pearson 相关系数为 0.33；P<.001）。基于 0.9 毫米的阈值，发现 CAWT 增加与 LA 之间存在重要的统计学关联（P<.0001）。使用相同的阈值，ROC 曲线分析表明对于 LA，CAWT 增加的敏感性为 55%，特异性为 75%。
结论
本研究结果表明 CAWT 增加与 LA（及其严重程度）之间存在统计学显著相关性。
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